Abr 27

Prótesis articulares y dispositivos relacionados con infecciones ortopédicas. El papel de la biopelícula en la patogénesis y tratamiento.

Prosthetic Joint and Orthopedic Device Related Infections. The role of biofilm in the Pathogenesis and Treatment


Este artículo es originalmente publicado en:



Antony S, Farran Y1.

Infect Disord Drug Targets. 2016 Apr 7. [Epub ahead of print]
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© 2016 Bentham Science Publishers



Prosthetic joint infections (PJI) in orthopedic related devices (ORD) are major issues following replacement of joints. It results in serious morbidity and mortality and is expensive to treat and manage. The pathogenesis of these infections is related to the presence of biofilm on the metallic and plastic surfaces of the devices. This biofilm results in poor penetration of antibiotics resulting in persistence and difficulty in eradication of the infection despite appropriate antibiotics. This paper summarizes the present data of biofilm as it relates to PJI/ORD.


Las infecciones de prótesis articulares (PJI) en dispositivos ortopédicos relacionados (ORD) son cuestiones importantes después del reemplazo de articulaciones. Es el resultado de la morbilidad y mortalidad graves y es costoso para tratar y manejar. La patogénesis de estas infecciones está relacionado con la presencia de biofilm sobre las superficies metálicas y de plástico de los dispositivos. Este biofilm se traduce en una pobre penetración de los antibióticos que resulta en la persistencia y la dificultad en la erradicación de la infección a pesar de los antibióticos apropiados. Este documento resume los datos actuales de la biopelícula que se refiere a PJI / ORD.

PMID: 27052335 [PubMed – as supplied by publisher]






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